A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 33/32 (2006.01) A61K 49/18 (2006.01)
Patent
CA 2107695
ABSTRACT This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound. In a preferred embodiment, the organ rich in mitochondria is the liver. In a further preferred embodiment, the particles are substantially nonmagnetic. In another preferred embodiment, the particles have a particle size of less than about 10 microns. In a still further preferred embodiment, the insoluble manganese compound is a manganese salt. The manganese compound is preferably selected from the group consisting of manganese phosphate, manganese carbonate and manganese 8-hydroxy quinolate. In another preferred embodiment, the composition of the present invention further comprises a surfactant. The present invention is further directed to a method of preparing a magnetic resonance imaging composition useful for imaging an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound comprised of contacting a manganese source with a counter ion source for a time and under conditions sufficient for the formation of said insoluble manganese compound. In a preferred embodiment, the contacting is by simultaneous admixing in an aqueous solution. The present invention is also directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of particles of a substantially insoluble manganese compound suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.
Gunther Wolfgang H. H.
Karpinski Piotr H.
Kellar Kenneth E.
Liversidge Elaine
Mcintire Gregory L.
Fetherstonhaugh & Co.
Nanosystems L.l.c.
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