G - Physics – 01 – N
Patent
G - Physics
01
N
167/44, 117/47.3
G01N 33/549 (2006.01) C08J 3/215 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/58 (2006.01)
Patent
CA 1289877
WATER-INSOLUBLE PARTICLE AND IMMUNOREACTIVE REAGENT, ANALYTICAL ELEMENTS AND METHODS OF USE Abstract of the Disclosure A water-insoluble polymeric particle has an inner core comprising a detectable tracer material distributed in a first polymer for which the tracer material has a high affinity. This first polymer has a glass transition temperature (Tg1) less than about 100°C. The particle also has an outer shell comprising a second polymer for which the tracer material has substantially less affinity relative to said first polymer. This second polymer has a glass transition temperature (Tg2) which is greater than or equal to the term [Tg1-10°C]. It also contains groups which are either reactive with free amino or sulfhydryl groups of an immunoreactive species or which can be activated for reaction with such groups. Such a species can be covalently attached to this particle to form an immunoreactive reagent which is useful in analytical elements and various analyti- cal methods including immunological methods, for ex- ample, agglutination assays.
555924
Danielson Susan J.
Littlehale Susan B.
Sutton Richard C.
Danielson Susan J.
Eastman Kodak Company
Gowling Lafleur Henderson Llp
Littlehale Susan B.
Sutton Richard C.
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