Water-insoluble preparations of peptide materials, their...

Details Water-insoluble preparations of peptide materials, their... Water-insoluble preparations of peptide materials, their...

C - Chemistry, Metallurgy

08

G

400/1211, 402/18

C08G 81/02 (2006.01) A61K 31/78 (2006.01) C08F 8/00 (2006.01) C08F 20/20 (2006.01) C12N 11/08 (2006.01)

Patent

CA 1036745

Abstract of the Disclosure There are disclosed water-insoluble proteinic preparations in which a protein or polypeptide is bound to a copolymer, which preparations are useful for binding enzymes in order to carry out enzyme-catalyzable reactions. These preparations comprise a peptide material bound to a cross- linked copolymer comprising the following copolymerized units: (A) about 0.1 to 30 wt. % of at least one .alpha.,.beta.- monoolefinically unsaturated dicarboxylic acid anhydride having about 4 to 9 carbon atoms; (B) about 35 to 90 wt. % of at least one di- and/or poly(meth)acrylate of a diol and/or polyol as hereinafter de- fined; and (C) about 5 to 60 wt. % of at least one hydrophilic monomer, the copolymer having a bulk volume of 1.4 to 30 ml/g and a specific surface area of about 1 to 500 m2/g, and containing, after saponification of the anhydride groups, about 0.01 to 14 milliequivalents of acid per gram. - 1 -

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