Water relaxation-based sensors

Details Water relaxation-based sensors Water relaxation-based sensors

G - Physics

01

R

G01R 33/465 (2006.01)

Patent

CA 2606924

This invention relates to magnetic resonance-based sensors and related methods . More specifically, the invention relates to a sensor based on magnetic resonance for detecting the presence of an analyte in a sample solution. The sensor comprises magnetic nanoparticles linked to a moiety upon which the analyte can reversibly bind, the nanoparticles being confined in a chamber with semipermeable walls which are impermeable to the nanoparticles but permeable to the analyte. Upon binding of the analyte to the nanoparticles, the latter aggregate which can be deteceted by a change in the T2 relaxation time of the sample solution within the chamber (magnetic relaxation switch) . The analyte may be a carbohydrate such as glucose, an antibody, an amino acid, a nucleic acid, an oligonucleotide, a therapeutic agent, a peptide, a protein, etc. The sensor may be used as an assay and may be read out using MRS or MRI, e.g. of well plates for high throughput anaylsis .

L'invention concerne des capteurs à résonance magnétique et des procédés associés.

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