C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/4025 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 9/12 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C07D 225/06 (2006.01)
Patent
CA 2338000
The present invention provides water-soluble drugs of the formula, (see above formula) in particular, a water-soluble analogues of geldanamycin, and compositions comprising the same. This invention also provides a method of rendering water-insoluble drugs soluble in water through derivatization with a bifunctional linking molecule and subsequent conjugation to a polar moiety through a thio ether. The present invention further provides use of the compounds to treat cancer that expresses heat shock protein 90 (Hsp90) in a mammal.
L'invention concerne des médicaments solubles à l'eau, en particulier des analogues solubles à l'eau de geldanamycine et des compositions contenant ces derniers. L'invention concerne également un procédé permettant de rendre solubles dans l'eau des médicaments normalement insolubles à l'eau au moyen d'une dérivatisation avec une molécule de liaison bi-fonctionnelle suivie d'une conjugaison à une fraction polaire par l'intermédiaire d'un thio-éther. L'invention concerne en outre une méthode de traitement du cancer chez le mammifère.
Alvarado-Lindner Ada Belinda
Ho David K.
Mandler Raya
Newman David J.
Upadhyay Kaye B. Dillah
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
R. William Wray & Associates
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