Water-soluble adenosine kinase inhibitors

Details Water-soluble adenosine kinase inhibitors Water-soluble adenosine kinase inhibitors

C - Chemistry, Metallurgy

07

H

C07H 19/14 (2006.01) C07H 19/04 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2247983

This invention relates to adenosine kinase inhibitors and to nucleoside analogs, specifically to orally active, substituted 5-aryl pyrrolo[2,3-d] pyrimidine and 3-aryl pyrazolo[3,4-d] pyrimidine nucleoside analogs having activity as adenosine kinase inhibitors. The invention also relates to the preparation and use of these and other adenosine kinase inhibitors in the treatment of cardiovascular and cerebrovascular diseases, inflammation and other diseases which can be regulated by increasing the local concentration of adenosine.

L'invention concerne des inhibiteurs de l'adénosine kinase et des analogues nucléosidiques, en particulier les formes actives par voie orale d'analogues du 5-aryl substitué pyrrolo[2,3-d]pyrimidine nucléoside et du 3-aryl substitué pyrazolo[3,4-d]pyrimidine nucléoside ayant une activité d'inhibiteur de l'adénosine kinase. L'invention concerne également la préparation et l'utilisation de ces composés et d'autres inhibiteurs de l'adénosine kinase pour le traitement de maladies cardiovasculaires et cérébrovasculaires, d'inflammations et d'autres maladies qui peuvent être traitées en augmentant la concentration locale d'adénosine.

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