Water soluble analgesic formulations and methods for production

Details Water soluble analgesic formulations and methods for production Water soluble analgesic formulations and methods for production

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2613281

A water soluble analgesic composition includes a plurality of granules. Each of the granules includes a substrate core and a coating disposed on the substrate core forming an agglomerated product, the coating including a salt of an analgesic, but substantially no particles of a non-salt form of the analgesic. The composition may be created by a method including the steps of: (i) providing a first solution comprising a base, (ii) adding an analgesic to the first solution to create a second solution including a salt of the analgesic, (iii) filtering the second solution to remove residual particles of the analgesic to create a filtered second solution, and (iv) spray drying the filtered second solution onto a substrate to form an agglomerated product having a plurality of granules.

La présente invention concerne une composition analgésique hydrosoluble qui inclut une pluralité de granules. Chaque granule inclut un cAEur de substrat et un enrobage disposé sur le cAEur de substrat pour former un produit aggloméré. L'enrobage inclut le sel d'un analgésique mais pratiquement aucune particule de l'analgésique qui ne soit pas sous forme de sel. La composition peut être fabriquée selon un procédé qui inclut les étapes suivantes : (i) formation d'une première solution comprenant une base, (ii) addition d'un analgésique à la première solution pour former une seconde solution incluant un sel de l'analgésique, (iii) filtration de la seconde solution pour éliminer les particules résiduelles de l'analgésique afin de constituer une seconde solution filtrée et (iv) sécher par pulvérisation la seconde solution filtrée sur un substrat pour former un produit aggloméré comportant une pluralité de granules.

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