Water soluble analogs and prodrugs of paclitaxel

Details Water soluble analogs and prodrugs of paclitaxel Water soluble analogs and prodrugs of paclitaxel

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/337 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2341234

The invention relates to water soluble antitumor analogs of paclitaxel of formula (I) wherein R1 = C(O)CH2CH(OH)COOX, R2 = H, C(O)CH2CH(OH)COOX, X = H, Li, Na or any other pharmaceutically acceptable counterion, as well as to a pharmaceutical composition comprising an antineoplastically effective amount of such analogs as an active ingredient.

La présente invention concerne des analogues antitumoraux hydrosolubles de paclitaxel représentés par la formule (I) dans laquelle on a R¿1? = C(O)CH¿2?CH(OH)COOX, R¿2? = H, C(O)CH¿2?CH(OH)COOX, X = H, Li, Na ou tout contre-ion pharmaceutiquement admis. L'invention concerne également une composition pharmaceutique dont le principe actif est une quantité antinéoplasiquement suffisante de tels analogues.

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