Water soluble, antineoplastic derivatives of taxol

Details Water soluble, antineoplastic derivatives of taxol Water soluble, antineoplastic derivatives of taxol

C - Chemistry, Metallurgy

07

D

167/207, 260/368

C07D 305/14 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1330436

ABSTRACT OF THE DISCLOSURE Antineoplastic water soluble derivatives of taxol having the following formula: Image wherein: Z = ethylene, propylene, CHCH, 1,2-cyclohexane, 1,2-phenylene R1= OK x base, NR2R3, OR3, SR3, OCH2CONR4R5, OH R2= hydrogen, methyl R3= (CH2)nNR6R7; (CH2)nN+R6R7R8X n = 1 to 3 R4= hydrogen, lower alkyl containing 1 to 4 carbons R5= hydrogen, lower alkyl containing 1 to 4 carbons, benzyl, hydroxyethyl, CH2CO2H, dimethylaminoethyl R6R7= lower alkyl containing 1 or 2 carbons, benzyl or R6 and R7 together with the nitrogen atom of NR6R7 form the following rings Image R8= lower alkyl containing 1 or 2 carbons, benzyl X = halide base= NH3, (HOC2H4)3N, N(CH3)3, CH3N(C2H4OH)2, NH2(CH2)6NH2, N-methylglucamine, NaOH, KOH. These derivatives have utility in the treatment of cancer.

592894

Affiliated with

Also associated with

Rating

Water soluble, antineoplastic derivatives of taxol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Water soluble, antineoplastic derivatives of taxol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Water soluble, antineoplastic derivatives of taxol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1202798