Water-soluble benzothiazine dioxide salts

Details Water-soluble benzothiazine dioxide salts Water-soluble benzothiazine dioxide salts

C - Chemistry, Metallurgy

07

D

260/243.21

C07D 417/12 (2006.01)

Patent

CA 1196639

WATER-SOLUBLE BENZOTHIAZINE DIOXIDE SALTS Abstract The water-soluble lysine and arginine salts of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3- carboxamide 1,1-dioxide have been prepared. These novel salts are useful in therapy as non-steroidal anti-arthritic agents, especially when administered by the parenteral route. Methods for preparing these salts from the corresponding acidic starting material and the appropriate amine base are provided.

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