Water soluble bis-dioxopiperazine derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 241/08 (2006.01) C07D 403/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2065291

2065291 9200971 PCTABS00010 An acid addition salt of a bis-dioxopiperazine derivative represented by general formula (I), wherein R1 represents C1 to C6 alkyl; R2 represents hydrogen or (a); R3 represents hydrogen, C1 to C6 alkyl or -(CH2)n-A, wherein A represents carboxyl, benzyloxycarbonyl, mercapto, amino, benzyloxycarbonylamino or (b), wherein X represents hydrogen, trifluoromethyl, hydroxy, acetoxy or benzyloxy, and n represents an integer of 1 to 4; and R4 represents hydrogen or alternatively R4 and R3 are combined together to represent a 5-membered cyclic group optionally containing sulfur.

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