Water soluble complex of penicillin acylase bonded to polymer

Details Water soluble complex of penicillin acylase bonded to polymer Water soluble complex of penicillin acylase bonded to polymer

C - Chemistry, Metallurgy

12

P

195/67, 195/99,

C12P 37/06 (2006.01) C07D 499/00 (2006.01) C07D 499/10 (2006.01) C07D 499/42 (2006.01) C07D 499/62 (2006.01) C12N 11/08 (2006.01) C07D 499/04 (2006.01)

Patent

CA 1061266

ABSTRACT: 6-Aminopenicillanic acid is prepared by enzymatic degradation of benzylpenicillin or of phenoxymethylpenicillin at pH 6.0-9.0 using a novel water-soluble enzyme complex derived from a penicillin deacylase enzyme bonded to a water-soluble polymeric material, the formed 6-aminopenicillanic acid being separated from the complex by an ultrafiltration technique, the said complex being recycled for re-use and the formed 6-aminopenicillanic acid being recovered. Preferably the complex is formed from a maleic acid copolymer or a modified polysaccharide, especially from a sucrose-epichlorhyarin copolymer.

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