C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/34 (2006.01) C07D 311/16 (2006.01) C12Q 1/42 (2006.01)
Patent
CA 2322205
Fluorescent enzyme substrates are provided. The substrates are derivatives of coumarin having an enzyme cleavable group at position 7 and a hydrophilic amide group at position 4. The compounds are highly water soluble, stable at ambient and reduced temperatures and fluoresce upon cleavage by an enzyme.
L'invention concerne des substrats d'enzymes fluorescents. Les substrats sont des dérivés de coumarine possédant un groupe enzyme clivable à la position 7 et un groupe amide hydrophile à la position 4. Les composés sont hautement solubles dans l'eau, stables à température ambiante et à température basse et émettent une fluorescence après clivage par une enzyme.
Huff Jeffrey B.
Merchant Barbara T.
Mullen Carolyn R.
Tata Venkata Seshagiri R.
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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