Water soluble crosslinked polymers

Details Water soluble crosslinked polymers Water soluble crosslinked polymers

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2688491

Compositions for siRNA delivery are described which include water soluble degradable crosslinked cationic polymers having a water soluble polyethylene glycol component, a cationic polyethyleneimine component and a degradable unit component. The composition may be used to deliver siRNA to cells, particularly cancer cells. The composition may be applied to a solid surface such as a multiwell plate so that the delivery of siRNA may be carried out on the solid surface.

L'invention concerne des compositions pour délivrer de l'ARNsi qui comprennent des polymères cationiques réticulés dégradables solubles dans l'eau ayant un composant poly(éthylène glycol) soluble dans l'eau, un composant poly(éthylèneimine) cationique et un composé de motif dégradable. La composition peut être utilisée pour délivrer de l'ARNsi à des cellules, en particulier à des cellules cancéreuses. La composition peut être appliquée à une surface solide telle qu'une plaque multipuits de sorte que l'administration d'ARNsi peut être réalisée sur la surface solide.

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