C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01) A61K 31/435 (2006.01) C07D 317/66 (2006.01) C07D 319/18 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01)
Patent
CA 2161681
The present invention relates to water soluble, camptothecin derivatives of formula (I), wherein: n represents the integer 1 or 2; and i) R1 represents: hydrogen, lower alkyl, (C3-7)cycloalkyl, (C3-7)cycloalkyl lower alkyl, lower alkenyl, hydroxy lower alkyl, amino lower allcyl, lower alkylamino lower alkyl, amino lower alkyl, lower alkoxy lower alkyl or (CH2)tAr wherein: t is 0 to 5 and Ar represents phenyl, furyl, pyridyl, N-methylpyrrolyl, imidazolyl; or phenyl, furyl, pyridyl, N-methylpyrrolyl, imidazol, with one or more substituents independently selected from hydroxy, methoxy, halogen, and amino; and R2 represents: diphenylmethyl or (CH2)tAr; or ii) R1 and R2 taken together with the linking nitrogen represent N-tetrahydroquinolyl or N-tetrahydroisoquinolyl; and the pharmaceutically acceptable salts and solvates thereof, their use in the treatment of tumors and methods of their preparation.
Besterman Jeffrey Mark
Evans Michael Glenn
Luzzio Michael Joseph
Myers Peter Leslie
Besterman Jeffrey Mark
Evans Michael Glenn
Fetherstonhaugh & Co.
Glaxo Inc.
Glaxo Wellcome Inc.
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