Water soluble derivatives of glycoside bioflavonoids,...

Details Water soluble derivatives of glycoside bioflavonoids,... Water soluble derivatives of glycoside bioflavonoids,...

C - Chemistry, Metallurgy

07

H

167/202, 260/233

C07H 15/26 (2006.01) A61K 31/70 (2006.01) C07H 17/075 (2006.01)

Patent

CA 2026540

The derivatives of glycoside bioflavonoids having general formula: (see formula I) wherein P represents the flavonic residue containing phenolic hydroxyls and R1 represents H, (CO-R-CO-O-N)n , in which X is selected among H, the cation of a pharmaceutically acceptable base and the radicals of polyoxyethylenglycols, polyoxypropylenglycols and their monomethylethers and R is an alkyl or aryl radical of a dicarboxylic acid, are water soluble and biodecomposable, maintaining at least the same therapeutical activity of the starting bioflavonoids. For their preparation the starting glycoside is reacted with the anhy- dride of the dicarboxylic acid , the resulting ether carboxylic derivative is reacted with a pharmaceutically acceptable base, for in- stance an alkali methal hydroxyde, carbonate or bicarbonate, or with polyoxyethylenglycol, polyoxypropylenglycol or their monomethylethers.

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