Water-soluble derivatives of lipophilic drugs

Details Water-soluble derivatives of lipophilic drugs Water-soluble derivatives of lipophilic drugs

G - Physics

01

N

G01N 33/94 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2473498

A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of the following formula: G-(L)nY ; where G is a lipophilic drug; L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms; n is 0 or 1; and Y is a water-sollubilizing group such as -SO3-, -NR-SO3- -P(=O)(OH)(O-), or -O- P(=O)(OH)(O-); where R is H or an alkyl group of 1 to 10 carbon atoms.

L'invention concerne un étalon de référence soluble dans l'eau, utilisé pour réaliser des dosages immunologiques de médicaments lipophiles. L'étalon de référence est un composé de la formule: G-(L)<sb>n</sb>Y, dans laquelle G est un médicament lipophile; L est un liant qui représente un groupe alkyle ou un groupe hétéroalkyle contenant 1 à 20 atomes de carbone; n est 0 ou 1; et Y est un groupe de solubilisation d'eau, tel que -SO<sb>3</sb><sp>-</sp>, -NR-SO<sb>3</sb><sp>-</sp> -P(=O)(OH)(O<sp>-</sp>), ou -O-P(=O)(OH)(O<sp>-</sp>) (R étant H ou un groupe alkyle comprenant 1 à 20 atomes de carbone).

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