Water soluble drug complex and method for production of same

Details Water soluble drug complex and method for production of same Water soluble drug complex and method for production of same

A - Human Necessities

61

K

167/100, 167/163

A61K 9/50 (2006.01) A61K 9/127 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1238853

ABSTRACT OF THE DISCLOSURE The invention provides a method of producing a water-soluble complex comprising a water-insoluble drug and a phospholipid, comprising the steps of (1) dissolving a water-insoluble drug and a phospholipid in an organic solvent, (2) removing the solvent to leave behind a drug- containing phospholipid film, (3) suspending the resulting film in an aqueous solution, (4) ultrasonicating the film, (5) centrifuging the resulting suspension, and (6) recovering the lowermost layer of the resulting sediment to yield the water-soluble complex. The above complex can be administered parenterally as well as by the oral and other routes, and is so rich in the drug component that a remarkably increased drug activity can be realized.

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