Water soluble guanidine derivatives of polyene macrolides...

Details Water soluble guanidine derivatives of polyene macrolides... Water soluble guanidine derivatives of polyene macrolides...

C - Chemistry, Metallurgy

07

H

260/230.35

C07H 17/08 (2006.01)

Patent

CA 1159053

ABSTRACT New guanidine derivatives of polyene macrolides having at least one free amino group and at least one free carboxy group (e.g. nystatin, pimaricin, amphotericin B, candicidin and trichomycin) are prepared by reacting the macrolide with a carbodiimide of the formula:- RI-N=C=N-RII where RI and RII are independently alkyl, substituted alkyl, cycloalkyl, aralkyl, aryl or aroylalkyl. Esters and salts of the derivatives can also be formed. The new derivatives are water-soluble and can be used as anti-mycotic agents.

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