Water soluble metal and semiconductor nanoparticle complexes

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/04 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C09K 11/00 (2006.01) C23C 26/00 (2006.01) H01F 1/00 (2006.01) H01F 1/36 (2006.01) H01F 1/37 (2006.01)

Patent

CA 2495306

The invention provides a water soluble complex comprising an inner core of a metal or semi-conductor nanoparticle. The nanoparticle is coated with a hydrophobic ligand, which is encapsulated in a micelle. In an aqueous medium, the micelle comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell comprising a plurality of hydrophilic moieties, the hydrophobic core comprising a plurality of hydrophobic moieties, each hydrophobic moiety comprising at least one chain, each chain comprising a minimum of 8 atoms; wherein the total number of atoms in all chains for each moiety comprises at least 24 atoms. The micelle has a minimum average diameter of approximately 5 nm and a maximum average diameter of approximately 45 nm.

L'invention concerne un complexe soluble dans l'eau comprenant un noyau interne d'un métal ou une nanoparticule semi-conductrice. Ladite nanoparticule est recouverte d'un ligand hydrophobe qui est encapsulé dans une micelle. Dans un milieu aqueux, la micelle comprend une enveloppe hydrophile et un noyau hydrophobe, ladite enveloppe hydrophile renfermant une pluralité de groupes caractéristiques hydrophiles qui contiennent respectivement au moins une chaîne qui renferme un minimum de 8 atomes. Le nombre total d'atomes dans toutes les chaînes pour chaque groupe caractéristique englobe au moins 24 atomes. Ladite micelle présente un diamètre moyen minimal d'approximativement 5 nm et un diamètre moyen maximal d'approximativement 45 nm.

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