C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
260/220.2
C08B 37/16 (2006.01)
Patent
CA 1235691
ABSTRACT The invention relates to novel water-soluble mixed ethers of .beta.-cyclodextrin ( .beta.-CD) with ether substituents comprising (C1 and C2) alkyl, hydroxy (C2 to C4)alkyl and carboxy (C1 and C2) alkyl such as methylhydroxyethyl- .beta.-CD or hydroxy- ethyl-carboxy-methyl- .beta.-CD; hydroxyethyl-hydroxy propyl ethers are excepted. The process of the invention comprises reacting .beta.-cyclodextrin with at least two different alkylating, hydroxy- alkylating and/or carboxyalkylating etherifying agents (for example, methyl chloride, ethylene oxide and/or chloroacetic acid) in a basic, liquid reaction medium containing an alkali-metal hydroxide, water and, optionally, at least one organic solvent (for example, dimethoxyethane or isopropanol). The mixed ethers of .beta.-cyclodextrin can be employed in the known fields of applica- tion of cyclodextrins e.g. for the production of inclusion compounds, especially those with biological activity.
470113
Brandt Lothar
Felcht Utz-Hellmuth
Fetherstonhaugh & Co.
Hoechst Aktiengesellschaft
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