Water soluble nanoparticles of hydrophilic and hydrophobic...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2461890

This invention provides a soluble nano-sized particles formed of a core (Water- insoluble lipophilic )compound or hydrophilic compound and an amphiphilic polymer and which demonstrated improved solubility and/or stability. The lipophilic compound within the soluble nano-sized soluble ("Solu- nanoparticles") may consist of Phannaceutical compounds, food additives, cosmetics, agricultural products and veterinary products. The invention)also provides novel methods for preparing the nano-sized soluble Particles, as well as a novel chemiCal reactor for manufacturing an inclusion complex comprising the nano-sized soluble Particles.

L'invention concerne des particules nanométriques solubles formées d'un noyau (composé lipophile insoluble dans l'eau ou composé hydrophile) et d'un polymère amphiphile, lesdites particules présentant une meilleure solubilité et/ou stabilité. Ledit composé lipophile desdites particules nanométriques solubles peut se présenter sous la forme de composés pharmaceutiques, d'additifs alimentaires, d'agents cosmétiques, de produits agricoles et vétérinaires. L'invention concerne également de nouveaux procédés de fabrication desdites particules nanométriques solubles, ainsi qu'un nouveau réacteur chimique destiné à la fabrication d'un complexe d'inclusion contenant lesdites particules nanométriques solubles.

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