Water-soluble, non ionic radioopaque contrast agents (x-ray...

Details Water-soluble, non ionic radioopaque contrast agents (x-ray... Water-soluble, non ionic radioopaque contrast agents (x-ray...

C - Chemistry, Metallurgy

07

C

260/550.5

C07C 233/12 (2006.01)

Patent

CA 1089489

ABSTRACT OF THE DISCLOSURE .alpha., .omega.-bis-[5-(dihydroxyalkyl) aminocarbonyl-3- hydroxyacyl-amino-2,4,6-triiodo-benzoyl-amino]-oxaalkane compounds of the formula Image wherein R1 is Image R and R' are hydrogen or methyl, R2 is dihydroxyalkyl having 3 or 4 carbon atoms n is 2 or 3, m is an integer between 1 and 5, and n(m+1) is an integer between 4 and 12, are readily soluble in water to yield injectable radio- paque contrast compositions which are well tolerated and stable. The compounds are prepared in good yields by reacting a reactive derivative of a 5-(di-hydroxyalkyl)- aminocarbonyl-3-acyloxyacylamino-2,4,6-triiodo-benzoic acid with an .alpha.,.omega.-diamino-oxaalkane of the formula R - NH - CnH2n- (O- CnH2n) - NH - R

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