C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/46 (2006.01) A61K 49/04 (2006.01) C07C 243/38 (2006.01) C07D 309/12 (2006.01) C07D 317/24 (2006.01) C07D 319/06 (2006.01)
Patent
CA 2081905
Abstract Water-soluble, non-ionic X-ray contrast agents and method of preparing them New, non-ionic, monomeric and dimeric X-ray contrast agents with low osmotic pressure and very good solubility in water are described, wherein methylene groups are inserted into side chains of triiodised benzoic acid or triiodised isophthalic acid. Furthermore, a method of preparing these compounds is described, wherein a 5-acylamido-2,4,6-triiodoisophthalic acid amide or a 3,5-diacylamido-2,4,6-triiodobenzoic acid amide or 3,5-diacylamido-2,4,6-triiodobenzoic acid is reacted with an alkylation medium of the formula Image in a basic environment, where X signifies a halogen, a sulphonic acid ester or a common leaving group.
Bruns Wilfried
Kohler Gernot
Dr. Franz Kohler Chemie Gmbh
Kirby Eades Gale Baker
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