Water soluble paclitaxel derivatives

Details Water soluble paclitaxel derivatives Water soluble paclitaxel derivatives

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/337 (2006.01) A61K 31/381 (2006.01) A61K 31/4745 (2006.01) A61K 41/00 (2006.01) A61P 35/00 (2006.01) A61N 5/10 (2006.01)

Patent

CA 2303338

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

Cette invention a trait à des compositions solubles dans l'eau de paclitaxel et de docétaxel que l'on obtient en conjuguant le paclitaxel ou le docétaxel et un polymère soluble dans l'eau tel qu'un acide poly-glutamique, un acide poly-aspartique ou une poly-lysine. Elle concerne également des méthodes d'utilisation de ces compositions aux fins du traitement de tumeurs comme de maladies auto-immunes telles que la polyarthrite rhumatoïde. Dans certains modes de réalisation de cette invention, on enduit des stents implantables aux fins de la prévention de la resténose.

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