Water-soluble peptides affecting gonadal function

Details Water-soluble peptides affecting gonadal function Water-soluble peptides affecting gonadal function

C - Chemistry, Metallurgy

07

K

530/7.06

C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1154758

ABSTRACT WATER-SOLUBLE PEPTIDES AFFECTING GONADAL FUNCTION [im-Bzl D-His6]LRF and [D-His (im-Bzl), Pro9-NEt] LRF exhibit hydrophillicity comparable to that of LRF and act as superagonists exhibiting potencies, respectively, about 12 and more than 200 times that of LRF. The peptides or their nontoxic salts can be administered by intravenous, subcutaneous, sublingual, oral, intravaginal, intranasal or rectal routes. The peptides can be used to regulate fertility in male and female mammals, including human beings.

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