A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 9/08 (2006.01) A61K 9/107 (2006.01) A61K 38/00 (2006.01) A61K 38/02 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 38/22 (2006.01) A61K 38/36 (2006.01) A61K 45/00 (2006.01) A61K 47/12 (2006.01) A61K 47/28 (2006.01) A61K 47/48 (2006.01) A61P 43/00 (2006.01) C07K 7/00 (2006.01)
Patent
CA 2281049
A water-soluble composition containing a complex of an ionic pharmaceutically effective polypeptide selected from the group consisting of hedgehog proteins, bone morphogenetic proteins, growth factors, erythropoietin, thrombopoietin, G-CSF, interleukins and interferons, characterized in that said composition contains, in addition, an amphiphilic compound, said polypeptide and said amphiphilic compound forming an ionic complex, whereby the forming of the complex does not enhance the solubility of said polypeptide, is suitable for increasing the activity of the polypeptide and/or for the delayed release of the polypeptide.
Une composition hydrosoluble contenant un complexe formé d'un polypeptide ionique pharmaceutiquement efficace choisi parmi le groupe suivant : protéines de hérisson, protéines morphogénétiques de l'os, facteurs de croissance, érythropoïétine, thrombopoïétine, G-CSF, interleukines et interférons. La composition contient également un composé amphiphile, ce dernier et ledit polypeptide formant le complexe ionique. La formation du complexe n'améliore pas la solubilité dudit polypeptide, permet d'augmenter l'activité du polypeptide et/ou la libération prolongée du polypeptide.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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