C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/22 (2006.01) A61K 31/4465 (2006.01) A61P 7/02 (2006.01) C07D 211/42 (2006.01) C07D 211/46 (2006.01)
Patent
CA 2474027
The invention is concerned with novel water soluble N-(4-carbamimidoyl-phenyl)- glycine derivatives of Formula (I); wherein R1 to R4 and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, Ixa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
Cette invention concerne des dérivés de N-(4-carbamimidoyl-phényl)- glycine hydrosolubles représentés par la formule (I), ainsi que des sels de ces composés acceptables au plan physiologique. Dans cette formule, R?1¿ à R?4¿ et n sont comme définis dans le descriptif et dans les revendications. Ces composés, qui inhibent la formation des facteurs de coagulation Xa, Ixa et de la thrombine induite par le facteur VII et le facteur tissulaire, peuvent être utilisés comme médicaments.
Alig Leo
Groebke Zbinden Katrin
Obst Ulrike
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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