Water-soluble phenylpyridazine derivative and medicine...

C - Chemistry – Metallurgy – 07 – D

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C07D 237/14 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 9/10 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2518227

A phenylpyridazine derivative represented by the general formula (1): (1) (wherein R1, R2, R3, X, Y, Z, and n are the same as defined in the description) or a salt thereof; and a medicine containing the derivative or salt. The phenylpyridazine derivative has excellent interleukin-1.beta. production inhibitory activity and has high water solubility and high oral absorbability.

Cette invention se rapporte à un dérivé de phénylpyridazine représenté par la formule général (1) (où R?1¿, R?2¿, R?3¿, X, Y, Z et n sont tels que définis dans les pièces descriptibles de la demande) ou à un sel de ce dérivé ; ainsi qu'à un médicament contenant ce dérivé ou ce sel. Ce dérivé de phénylpyridazine possède un excellent effet inhibiteur contre la production d'interleukine-1.beta. et une grande solubilité dans l'eau, ainsi qu'une absorbabilité élevée par voie orale.

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