C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 237/14 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 1/04 (2006.01) A61P 9/00 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C07D 237/24 (2006.01)
Patent
CA 2461806
Compounds represented by the following general formula (1), which have an effect of inhibiting IL-.beta. production, are highly soluble in water and have a favorable oral absorbability, and medicinal compositions containing the same: (1) wherein R1 represents alkyl, alkenyl, etc.; R2 and R3 represent each hydrogen, alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl, or R2 and R3 may form together with the adjacent nitrogen atom an optionally substituted nitrogen-containing saturated heterocyclic group; X, Y and Z represent each hydrogen, alkyl, halogeno, etc.; and n is from 1 to 5.
L'invention concerne des composés ayant pour effet d'inhiber la production d'IL-.beta., hautement solubles dans l'eau et présentant une bonne absorbabilité orale, et des compositions médicales contenant lesdits composés représentés par la formule générale suivante (1) dans laquelle R?1¿ représente alkyle, alcényle, etc.; R?2¿ et R?3 ¿représentent chacun hydrogène, alkyle, hydroxyalkyle, dihydroxyalkyle ou alcynyle, ou R?2 ¿et R?3 ¿peuvent former ensemble avec l'atome d'azote adjacent un groupe hétérocyclique saturé contenant de l'azote éventuellement substitué; X, Y et Z représentent chacun hydrogène, alkyle, halogéno, etc.; et n est compris entre 1 et 5.
Kitamura Takahiro
Koshi Tomoyuki
Kyotani Yoshinori
Sato Seiichi
Shigyo Hiromichi
Kowa Co. Ltd.
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