Water-soluble pro-drugs of propofol

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 9/00 (2006.01) C07C 39/26 (2006.01) C07C 39/27 (2006.01) C07C 69/017 (2006.01) C07F 9/12 (2006.01)

Patent

CA 2331371

This invention provides optionally substituted esters of propofol (2,6- diisopropylphenol). The propofol esters are soluble in water and metabolize rapidly to propofol in the body. The propofol esters are useful as pro-drugs for the same indications as propofol. This invention also provides methods of treating neurodegenerative diseases by administering an effective amount of propofol.

L'invention concerne des esters de propofol (2,6-diisopropylphénol) éventuellement substitués. Ces esters de propofol sont solubles dans l'eau et se métabolisent rapidement en propofol dans le corps. Les esters de propofol sont utiles en tant que promédicaments pour les mêmes indications que le propofol. L'invention concerne également des méthodes de traitement de maladies neurodégénératives par administration d'une dose efficace de propofol.

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