Water soluble rapamycin esters

Details Water soluble rapamycin esters Water soluble rapamycin esters

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/436 (2006.01) A61K 47/48 (2006.01) C07D 498/18 (2006.01) C07H 19/01 (2006.01) C08G 65/329 (2006.01)

Patent

CA 2193329

A compound of the structure (See formula I) wherein R1 and R2 are each, independently, hydrogen or -COCH2-S-CH2CH2-O-CH2-(CH2OCH2)n-CH2-O-CH2CH2-OCH3; and n = 8 - 450; with the proviso that R1 and R2 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.

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