Water soluble sdz-rad esters

Details Water soluble sdz-rad esters Water soluble sdz-rad esters

C - Chemistry, Metallurgy

07

D

C07D 498/18 (2006.01) A61K 31/445 (2006.01) A61K 47/48 (2006.01) C07D 221/00 (2006.01) C07D 273/00 (2006.01) C07D 311/00 (2006.01) C08G 65/329 (2006.01) C08G 65/334 (2006.01)

Patent

CA 2391319

The invention provides novel water soluble pegylated esters of rapamycin, having general structure (I), wherein n is an integer from about 5 to about 450, as well as pharmaceutical compositions containing these compounds and methods for their use as immunosuppressive, anti-inflammatory, antifungal, antiproliferative and antitumor agents.

Cette invention concerne des esters polyéthylèneglycolés hydrosolubles de rapamycine représentés par la structure générale (I) dans laquelle n est un entier compris entre 5 et 450 environ. L'invention porte également sur des compositions pharmaceutiques renfermant ces composés ainsi que sur leur utilisation sous forme d'agents immunosuppresseurs, anti-inflammatoires, antifongiques, antiprolifération et antitumoraux.

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