C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/36 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4427 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 33/00 (2006.01) C07C 251/82 (2006.01) C07D 205/10 (2006.01) C07D 277/56 (2006.01) C07D 417/06 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2718436
Provided herein are highly water soluble, thiazolidinone derivative compounds and glycine hydrazide derivative compounds that inhibit the ion transport activity of the cystic fibrosis transmembrane conductance regulator (CFTR). The compounds, and compositions comprising the compounds, described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea. The compounds may also be used for inhibiting expansion or preventing formation of cysts in persons who have polycystic kidney disease.
La présente invention concerne des composés dérivés de thiazolidinone hautement soluble dans l'eau et des composés dérivés de glycine hydrazine qui inhibent l'activité de transport ionique du régulateur de conductance transmembranaire de fibrose kystique (CFTR). Les composés et compositions comprenant les composés décrits ici sont utiles pour traiter des maladies, troubles et séquelles de maladies, troubles et des affections qui sont associés à une activité de CFTR accrue de façon aberrante, par exemple, une diarrhée sécrétoire. Les composés peuvent également être utilisés pour inhiber une propagation ou empêcher une formation de kystes chez les personnes ayant une maladie rénale polykystique.
Sonawane Nitin D.
Verkman Alan S.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Regents Of The University Of California
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