A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 9/127 (2006.01) A61K 9/51 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61K 31/277 (2006.01) A61K 31/282 (2006.01) B29C 39/24 (2006.01) C07K 19/00 (2006.01) C12N 15/88 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2452806
The present invention is directed toward water-soluble supramolecular self- assemblies and a process for their preparation via micellization of polyelectrolytes through the use of hydrophobic monomeric units. In this invention the polyelectrolyte segment ultimately forms the core of the supramolecular assembly whereas the shell consists of uncharged hydrophobic polymers or oligomers. It has been determined that the inclusion of the hydrophobic co-monomers to the polyelectrolyte segment forming the micelle core leads to a structure of enhanced stability.
La présente invention concerne des autoassemblages supramoléculaires solubles dans l'eau et un procédé permettant leur préparation par micellisation de polyélectrolytes par utilisation d'unités monomères hydrophobes. Dans cette invention, le segment polyélectrolytique forme à la fin le coeur de l'assemblage supramoléculaire alors que l'enveloppe est constituée de polymères ou d'oligomères hydrophobes non chargés. Il a été déterminé que l'inclusion de co-monomères hydrophobes au segment polyélectrolytique formant le coeur de micelle permet d'obtenir une structure de stabilité améliorée.
Leroux Jean-Christophe
Ranger Maxime
Borden Ladner Gervais Llp
Labopharm Inc.
Labopharm (barbados) Limited
Labopharm Europe Limited
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