Water-soluble strontium salts for use in treatment of...

A - Human Necessities – 61 – K

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A61K 33/24 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2519189

Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water- solubility of from about 1g/l to about 100g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.

L'invention concerne des composés et des compositions pharmaceutiques pour le traitement et/ou la prophylaxie d'affections de cartilage et/ou d'os, et utilisables en liaison avec des procédés de traitement correspondants. Il s'agit de sels de strontium ayant une hydrosolubilité comprise entre 1g/l et environ 100g/l à température ambiante, en particulier des sels d'acides aminés de strontium ou des sels d'acide dicarboxylique de strontium. On donne des exemples de sels de strontium hydrosolubles, par exemple glutamate de strontium et alpha-cétoglutarate de strontium. L'invention concerne également un procédé amélioré de préparation de sel d'acide glutamique de strontium.

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