Water soluble transplatinum complexes with anti-cancer...

A - Human Necessities – 61 – K

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A61K 31/28 (2006.01) C07F 15/00 (2006.01)

Patent

CA 2366048

The present invention relates to the treatment of tumors with a novel water soluble trans-platinum coordination compound having the general structural formula [PtBXm(NR*3)] where B is a planar, heterocyclic ring containing at least one nitrogen atom, and a pendant chelating group; and X is an anionic ligand; and R* is hydrogen or a lower alkyl.

La présente invention concerne le traitement de tumeurs à l'aide d'un nouveau composé de coordination de trans-platine soluble dans l'eau, représenté par la formule de structure générale [PtBX¿m?(NR*¿3?)] dans laquelle B est un noyau hétérocyclique plane contenant au moins un atome d'azote et un groupe chélatant libre; et X est un ligand anionique; et R* représente un hydrogène ou un alkyle inférieur.

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