Water-soluble triazole antifungal agents

Details Water-soluble triazole antifungal agents Water-soluble triazole antifungal agents

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/41 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/675 (2006.01) A61P 31/10 (2006.01) C07D 249/08 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01) C07F 9/6518 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2439001

A triazole compound of the general formula (I) or a pharmacologically acceptable salt thereof: (see formula I) wherein X represents a group of formula X-OH which has antifungal activity, L represents a -(adjacently substituted C6-C10 aryl) -CH2-group and the like, and R represents a -P(=O)(OH)2 group and the like.

L'invention concerne un composé triazole représenté par la formule (I) dans laquelle X représente un groupe tel que le composé représenté par la formule X-OH possède une activité antifongique, L représente notamment un groupe (C¿6-10?aryle) CH¿2?- dans lequel le groupe aryle porte des substituants sur les atomes de carbone voisins, et R représente notamment un groupe P(=O) (OH¿2?). Elle concerne aussi un sel de ce composé, acceptable sur le plan pharmaceutique.

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