C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/22 (2006.01) A61K 31/40 (2006.01) A61K 31/555 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07B 59/00 (2006.01) C07F 5/00 (2006.01) C07F 13/00 (2006.01) C07J 43/00 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2147509
A group of novel expanded porphyrin-like compounds, porphacyanine (Pc) and porphacyanine-like compounds, having absorption maxima in the range of 400-850 nanometers is useful in detecting and treating targeted tissues, cells and viruses. The use of the Pc of the invention permits the irradiation to comprise wavelengths other than those absorbed by blood. The Pc of the invention may also be conjugated to target-specific moieties such as immunoglobulins or fragments thereof to target specific tis- sues or cells for the radiation treatment. Use of these materials permits greater depth of treatment penetration and greater specif- icity in targeting tissues or cells. Coupled with an appropriate paramagnetic or radioisotope, the Pc of the invention is suitable for use in nuclear magnetic resonance imaging and radioimaging. Novel methods for synthesizing the Pc of the invention are dis- closed.
Dolphin David
Tang Hang
Wijesekera Tilak
Xie Lily
Fetherstonhaugh & Co.
Quadra Logic Technologies Inc.
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