C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 5/10 (2006.01) C07K 5/117 (2006.01) C07K 7/04 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 17/00 (2006.01) C12N 9/12 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2182299
The present invention relates to a polypeptide composition effective to alter the activity of a first protein that interacts with a second protein, where the second protein contains at least one WD-40 region. The polypeptides of the present invention typically have between 4 and 50 amino acids whose sequence is the same as a sequence of the same length in the WD-40 region of the second protein. The invention further includes a method of altering the activity of the above described first protein. In one embodiment of the invention the polypeptide composition is effective to alter the activity of a protein kinase C, where the protein kinase C interacts with a second protein, and the second protein contains at least one WD-40 region (e.g., RACK1).
La présente invention concerne une composition polypeptidique capable de modifier l'activité d'une première protéine qui interagit avec une seconde protéine contenant au moins une région WD-40. Les polypeptides de l'invention comportent entre 4 et 50 acides aminés de séquence similaire à une séquence de même longueur dans la région WD-40 de la seconde protéine. L'invention comprend en outre un procédé visant à modifier l'activité de la première protéine décrite ci-dessus. Selon un mode de réalisation de l'invention, la composition polypeptidique est capable de modifier l'activité d'une protéine kinase C, cette dernière interagissant avec une seconde protéine contenant au moins une région WD-40 (par exemple RACK1).
Mochly-Rosen Daria
Ron Dorit
Board Of Trustees Of The Leland Stanford Junior University (the)
Fetherstonhaugh & Co.
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