Weak base salts

Details Weak base salts Weak base salts

C - Chemistry, Metallurgy

07

D

C07D 421/00 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 403/02 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01)

Patent

CA 2515289

Pharmaceutical compositions comprising a salt of a weak base compound of formula: wherein X is hydrogen, halogen, alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl, ethyl or oxychloro; R is hydrogen, alkylaminocarbonyl wherein the alkyl group has from 3 to 6 carbon atoms or an alkyl group having from 1 to 8 carbons and R2 is 4-thiazolyl, NHCOOR1 wherein R, is aliphatic hydrocarbon of less than 7 carbon atoms, or an alkyl group of less than 7 carbon atoms; one or more free acids; and optional pharmaceutical additives are provided.

L'invention concerne des compositions pharmaceutiques comprenant: un sel d'un composé de faible basicité de formule (I) dans laquelle X est hydrogène, halogène, alkyle comportant moins de 7 atomes de carbone ou alcoxy comportant moins de 7 atomes de carbone; n est un entier positif inférieur à 4; Y est hydrogène, chlore, nitro, méthyle, éthyle ou oxychloro; R est hydrogène, alkylaminocarbonyle dont le groupe alkyle présente 3 à 6 atomes de carbone ou un groupe alkyle présentant 1 à 8 atomes de carbone; et R2 est thiazolyle, NHCOOR1, dans lequel R est un hydrocarbure aliphatique présentant moins de 7 atomes de carbone ou un groupe alkyle présentant moins de 7 atomes de carbone; un ou plusieurs acides libres; et des additifs pharmaceutiques facultatifs.

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