A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2749115
Methods for the treatment of CD30-expressing cancers are provided. The methods comprise administering to a subject in need thereof a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an antibody-drug conjugate compound having formula (I); or a pharmaceutically acceptable salt thereof; wherein: mAb is an anti-CD30 antibody unit, S is a sulfur atom of the antibody, A- is a Stretcher unit, and p is from about 3 to about 5.
La présente invention concerne des procédés pour le traitement de cancers exprimant CD30. Les procédés comprennent l'administration à un sujet nécessitant celle-ci d'une dose hebdomadaire d'environ 0,8 mg/kg à environ 1,8 mg/kg d'un composé conjugué anticorps-médicament ayant la formule (I) ; ou un sel pharmaceutiquement acceptable de celui-ci ; où : mAb est une unité d'anticorps anti-CD30, S est un atome de soufre de l'anticorps, A- est une unité d'extension, et p est d'environ 3 à environ 5.
Ihle Nathan
Kennedy Dana
Sievers Eric
Sun Michael
Fetherstonhaugh & Co.
Seattle Genetics Inc.
LandOfFree
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