Wet granulation formulation for bisphosphonic acids

Details Wet granulation formulation for bisphosphonic acids Wet granulation formulation for bisphosphonic acids

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2188567

Pharmaceutical compositions of bisphosphonic acids, and salts thereof, are prepared by wet granulation tablet formulation. These pharmaceutical compositions are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease. These compositions are prepared without the addition of binder; instead, the drug itself acts as a binder.

L'invention concerne des compositions pharmaceutiques d'acides bisphosphoniques, et leurs sels, se présentant sous forme de comprimés préparés à l'aide d'un procédé de granulation par voie humide. Ces compositions pharmaceutiques sont préconisées pour le traitement des troubles dus au métabolisme du calcium ou du phosphate, notamment pour le traitement et la prophylaxie des maladies impliquant la résorption osseuse, en particulier l'ostéoporose, la maladie de Paget, l'hypercalcémie maligne et la maladie osseuse métastatique. Les compositions selon l'invention sont préparées sans adjonction de liant, le médicament remplissant lui-même la fonction de liant.

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