Wet granulation of tenofovir, emtricitabine and efavirenz

Details Wet granulation of tenofovir, emtricitabine and efavirenz Wet granulation of tenofovir, emtricitabine and efavirenz

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2744211

The present invention describes a method and composition for a pharmaceutical product based on Tenofovir disoproxil hemifumarate, Emtricitabine and Efavirenz. The composition can be prepared by a process comprising a wet granulation step to produce a stable dosage form suitable for the treatment of HIV in essential absence of known degradation products.

La présente invention concerne une méthode et une composition de produit pharmaceutique basées sur le diisopropoxylhémifumarate de Tenofovir, lEmtricitabine et lEfavirenz. La composition peut être élaborée suivante un procédé comprenant une étape de granulation humide pour reproduire une forme galénique stable adaptée au traitement du VIH essentiellement en l'absence de produits de dégradation connus.

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