Wet granulation using a water sequestering agent

Details Wet granulation using a water sequestering agent Wet granulation using a water sequestering agent

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/538 (2006.01)

Patent

CA 2704474

Disclosed are tablets comprising hydrolytically stable formulations of (6-(5- fluoro-2-(3,4,5-trimethoxyphenylamino) pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)- yl)methyl phosphate disodium salt (Compound 1) prepared by a wet granulation process.

L'invention concerne des comprimés comprenant des formulations hydrolytiquement stables de sels de disodium de phosphate(6-(5-fluoro-2-(3,4,5-triméthoxyphénylamino) pyrimidin-4-ylamino)-2,2-diméthyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)méthyle (composé 1) préparé par un procédé de granulation par voie humide.

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