Wet milling process

Details Wet milling process Wet milling process

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61J 3/02 (2006.01) A61K 31/12 (2006.01) A61K 31/351 (2006.01) B02C 17/16 (2006.01) B02C 17/22 (2006.01)

Patent

CA 2413330

A process for preparing a finely divided preparation of a drug substance comprising wet milling a suspension of the drug substance in a mill having at least one chamber and agitation means, said chamber(s) and/or said agitation means comprising nylon, wherein the nylon comprises one or more internal lubricants results in finely divided preparations of a drug substance in which the level of grinding media contamination and process contamination are reduced.

L'invention concerne un procédé permettant de préparer une préparation concassée d'une substance médicamenteuse. Ce procédé consiste à broyer par voie humide une suspension de la substance médicamenteuse dans un broyeur comportant au moins une chambre et un moyen ou des moyens d'agitation. La ou les chambre(s) et/ou le(s) moyens d'agitation comprennent du Nylon. Ce Nylon comprend un ou plusieurs lubrifiants internes, ce qui permet d'obtenir des préparations concassées d'une substance médicamenteuse dans laquelle le niveau de contamination des milieux de broyage et la contamination du système sont diminués.

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