Wettable microcapsules having hydrophobic polymer coated cores

Details Wettable microcapsules having hydrophobic polymer coated cores Wettable microcapsules having hydrophobic polymer coated cores

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2328080

This invention concerns wettable microcapsules having hydrophobic polymer coated cores and to processes for their preparation; in particular, to microcapsules with hydrophobic polymer coats that are wettable so that they are suspendible in aqueous medium. The wettable microcapsules can be prepared by applying hydrophobic polymer onto a drug containing core by phase separation from a solvent to provide microcapsules, optionally washing said microcapsules with a solvent in which said microcapsules are substantially insoluble and drying, characterised in that: (a) one or more surfactants is/are incorporated in the solvent at the phase separation step; and/or (b) one or more surfactants is/are incorporated in the solvent used to wash the microcapsules; and/or (c) the microcapsule is coated with one or more surfactants optionally in the presence of a binder.

L'invention concerne des microcapsules pouvant s'humecter et comportant un noyau enrobé de polymère hydrophobe, ainsi que des procédés de préparation de ces microcapsules. Elle concerne notamment des microcapsules dont les enrobages polymères peuvent s'humecter, de manière à pouvoir être mises en suspension dans un milieu aqueux. Ce procédé de préparation consiste à appliquer un polymère hydrophobe sur un médicament contenant un noyau, par séparation en phases, à partir d'un solvant, afin d'obtenir des microcapsules, et, le cas échéant, à laver ces microcapsules à l'aide d'un solvant dans lequel elles sont sensiblement insolubles, puis à sécher les microcapsules, ce procédé étant caractérisé en ce que: (a) on incorpore un ou plusieurs tensioactifs dans le solvant au niveau de l'étape de séparation en phases; et/ou (b) on incorpore un ou plusieurs tensioactifs dans le solvant utilisé pour laver les microcapsules; et/ou (c) on enrobe la microcapsule d'un ou de plusieurs tensioactifs, le cas échéant, en présence d'un liant.

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