Whole cell assay for inhibitors of cathepsin k

Details Whole cell assay for inhibitors of cathepsin k Whole cell assay for inhibitors of cathepsin k

G - Physics

01

N

G01N 33/573 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/60 (2006.01)

Patent

CA 2539076

The present invention relates to a method of identifying and evaluating chemical inhibitors of cathepsin K activity in whole cells. The present invention also relates to probes that are capable of forming irreversible adducts with cathepsin K at the active site. The probes used in the instant invention comprise a radioactive functional group to allow the detection of the irreversible cathepsin K-probe adducts.

La présente invention concerne une méthode d'identification et d'évaluation des inhibiteurs chimiques de l'activité de la cathepsine K dans des cellules entières. La présente invention concerne également des sondes pouvant former des produits d'addition irréversibles avec la cathepsine K au niveau du site actif. Les sondes utilisées dans l'invention comprennent un groupe fonctionnel radioactif permettant de détecter les produits d'addition irréversibles formés par les sondes de la cathepsine K.

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