C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 245/18 (2006.01) C07F 13/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01) G01N 33/60 (2006.01)
Patent
CA 2539053
The present invention relates to a method of identifying and evaluating chemical inhibitors of cathepsin S activity in whole cells. The present invention also relates to probes that are capable of forming irreversible adducts with cathepsin S at the active site. The probes used in the instant invention comprise radioactive functional groups to allow the detection of the irreversible cathepsin S-probe adducts.
La présente invention concerne une méthode d'identification et d'évaluation des inhibiteurs chimiques de l'activité de la cathepsine S dans des cellules entières. La présente invention concerne également des sondes pouvant former des produits d'addition irréversibles avec la cathepsine S au niveau du site actif. Les sondes utilisées dans l'invention comprennent des groupes fonctionnels radioactifs permettant de détecter les produits d'addition irréversibles formés par les sondes de la cathepsine S.
Falgueyret Jean-Pierre
Mellon Christophe
Merck Frosst Canada Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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