Whole cell engineering using real-time metabolic flux analysis

Details Whole cell engineering using real-time metabolic flux analysis Whole cell engineering using real-time metabolic flux analysis

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C07K 1/16 (2006.01) C12M 1/34 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/01 (2006.01) C12P 21/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 27/62 (2006.01) G01N 30/00 (2006.01) G01N 30/06 (2006.01) G01N 30/26 (2006.01) G01N 30/34 (2006.01) G01N 30/46 (2006.01) G01N 30/60 (2006.01) G01N 30/72 (2006.01) G01N 30/84 (2006.01) G01N 30/86 (2006.01) G01N 30/88 (2006.01) G01N 31/00 (2006.01) G01N 31/22 (2006.01) G01N 33/48 (2006

Patent

CA 2462641

The invention provides methods for whole cell engineering of new and modified phenotypes by using "on-line" or "real-time" metabolic flux analysis. The invention provides a method for whole cell engineering of new or modified phenotypes by using real-time metabolic flux analysis by making a modified cell by modifying the genetic composition of a cell and culturing the modified cell to generate a plurality of modified cells and measuring at least one metabolic parameter of the cell by monitoring the cell culture of in real time. The invention also provides articles comprising machine-readable medium including machine-executable instructions and systems, e.g., computer systems, to practice the methods of the invention.

L'invention concerne des procédés d'ingénierie de cellule entière, concernant des phénotypes nouveaux et modifiés, par l'utilisation d'analyse de flux métabolique </= en ligne >/= ou </= en temps réel >/= . L'invention concerne un procédé de modification génétique de cellule entière, concernant de phénotypes nouveaux ou modifiés, par l'utilisation d'analyse de flux métabolique en temps réel, consistant à réaliser une cellule modifiée, c'est à dire à modifier la composition génétique d'une cellule et à cultiver cette cellule modifiée afin de produire de nombreuses cellules modifiées, et à mesurer au moins un paramètre métabolique de la cellule par suivi de la culture cellulaire en temps réel. L'invention concerne aussi des articles comportant un support lisible par machine comprenant des instructions exécutables par machine et de systèmes, par exemple, des systèmes informatiques, afin de pratiquer les procédés de l'invention.

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